GLP-1 Reconstitution Calculator
Enter your compounded peptide vial size and the amount of mixing water you add to get the exact concentration, how many units to draw on your insulin syringe, a full titration schedule, and a 7-day chart showing how much drug remains in your body. Nothing uploaded.
Results
7-Day Drug Level Chart ?
Titration Schedule ?
| Period | Dose mg | Syringe units | Volume (mL) |
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Learn more: GLP-1 reconstitution and dosing
How to calculate concentration and safe syringe unit dosing
Reconstitution is mixing a lyophilized (freeze-dried) peptide vial with bacteriostatic water (BAC water) to create an injectable solution. A 5mg vial mixed with 2.5mL water yields 2.0 mg/mL concentration - the key number for all dosing. To find your dose in syringe units: dose in units = (dose in mg / concentration in mg/mL) × 100. A 0.5mg dose at 2.0 mg/mL concentration = (0.5 / 2.0) × 100 = 25 units on a U-100 insulin syringe. Incorrect concentration calculations are the leading cause of dose errors. Always verify your vial size, water volume, and resulting concentration with your prescriber before drawing any doses. The calculator helps avoid arithmetic mistakes, but you bear responsibility for accuracy.
Understanding titration schedules and drug half-life in your system
Titration is a phased dose increase designed to minimize side effects. A typical schedule starts at 0.25mg weekly for 4 weeks, then 0.5mg, 1mg, 1.5mg, and 2mg, stepping up every 4 weeks until reaching maintenance. Your prescriber may use a different schedule based on your tolerance and goals - always follow their specific instructions, not a generic template. The 7-day decay chart shows that semaglutide has a half-life of approximately 7 days, meaning 50% clears per week. This is why weekly dosing works: each new 0.5mg injection adds to the ~0.25mg still circulating from the previous week, building to steady state around week 4-5. Missing a dose or taking it late delays steady state achievement.
FAQ
What is concentration and why does it matter for dosing?
Concentration is how much drug (in mg) is dissolved in each mL of liquid. A 5mg vial + 2.5mL BAC water = 2.0 mg/mL concentration. A 5mg vial + 5mL water = 1.0 mg/mL. Lower concentration = larger volume to draw (more syringe units). Higher concentration = smaller volume. You MUST know your exact concentration to calculate the correct syringe unit dose. Drawing the wrong units - especially with concentrated peptides - can cause serious dose errors.
What does the titration schedule mean and why is it important?
Titration is a gradual dose escalation (e.g., 0.25mg, 0.5mg, 1mg, 1.5mg, 2mg over weeks) that lets your body adapt and reduces nausea and side effects. Starting at the full maintenance dose causes severe GI distress in most people. The calculator shows you the week-by-week schedule and how many units of your specific concentration to draw each week. Always follow your prescriber's titration schedule, not the calculator's default.
What is the half-life and what does the 7-day chart show?
Half-life (approximately 7 days for semaglutide) is how long it takes for 50% of the drug to be cleared from your body. The 7-day chart shows the drug level declining after a single injection: 100% on day 0, ~50% on day 7, ~25% on day 14. This explains why weekly injections build up - each new dose adds to the lingering level from the previous week. Weekly dosing reaches steady state around week 4-5 where injection + residual level = therapeutic effect.